The aim of this blog is to encourage development and dissemination of knowledge of native protein structures at the quaternary level, that is, knowledge of the arrangements of subunits in functional proteins. The fundamental starting point of this discussion is that the arrangements seen in protein crystals are not necessarily the native arrangements.
Saturday, April 14, 2007
New Native Structures in Neuraminidases
Following on from the theory, I have produced model quaternary structures for a number of neuraminidase enzymes, based on the x-ray crystal structures. Click on these links to view this paper. html linked here. An earlier pdf version is linked here. The paper is copyright 2007 to myself, Dr Don Vanselow, 54 Greenways Road, Glen Waverley, Victoria 3150. Australia. All rights reserved.
The Fundamental Biophysics of Protein Function
The theory of catalysis and other functions displayed by soft biomaterials such as proteins is described in the paper "The Role of Constraint in Catalysis and High-Affinity Binding by Proteins" published in the Biophysical Journal in May 2002. Use the link provided by clicking on the title of this Post.
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