The aim of this blog is to encourage development and dissemination of knowledge of native protein structures at the quaternary level, that is, knowledge of the arrangements of subunits in functional proteins. The fundamental starting point of this discussion is that the arrangements seen in protein crystals are not necessarily the native arrangements.
Wednesday, June 24, 2009
Immunoglobulin structure
Last year I said that a full paper detailing all the haemoglobin work would be the next project for this blog. As it happens I realised a few months ago that IgG (an immunoglobulin) is like haemoglobin in being an α2β2 tetramer and so I explored tetrahedral rearrangements of the published crystal structure. This project has been very successful. I will present the IgG results on this blog before I complete the larger haemoglobin document.
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