The 2008 "Haemoglobin Revisited" poster presented at WATOC 08 has been accepted into the Faculty of 1000 Poster Collection and can be accessed by clicking on the heading of this post. It is slightly modified from the original by inclusion of the instructions for generating the structures and by crossing out the claim that the crystal structure cannot account for the inability to form crosslinks between the N-terminals of the beta chains. The crystal structure can account for this phenomenon if it is also assumed that the N-terminals are not very mobile. On the other hand, the native structure of the T-state proposed in the poster (click on the Gallery link) can account for the crosslinking properties only if the lysine side chains are considered mobile.
In summary, the crosslinking study cannot distinguish between these opposing views of protein structure.
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