The aim of this blog is to encourage development and dissemination of knowledge of native protein structures at the quaternary level, that is, knowledge of the arrangements of subunits in functional proteins. The fundamental starting point of this discussion is that the arrangements seen in protein crystals are not necessarily the native arrangements.
Thursday, May 5, 2011
Dihydrodipicolinate Synthase (DHDPS)
The structure of this enzyme from Bacillus anthracis is now available in the Gallery. It is the first alpha/beta barrel native quaternary structure to be reassembled. Using this structure as a template should help in the reassembly of other alpha/beta barrel structures. There is a ragged edge on the z-axis of this structure that corresponds to an area of inter-subunit contact in the crystal. Probably this is an example of damage to the tertiary structure caused by crystallization.
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